Beyond PEGylation: Engineering Novel PEG-Alternatives to Mitigate Anti- PEG Responses & Enable Repeatable LNP Delivery
- Bypassing accelerated blood clearance by reducing recognition from pre-existing and induced anti-PEG antibodies
- Structural design of PEG-alternatives that maintain nanoparticle stability and endosomal escape while minimising immune detection
- Reviewing in vivo and NHP data demonstrating sustained protein expression and low toxicity across longitudinal dosing cycles