Developing Polymer-Free Lipid Nanoparticles to Simplify Formulation & Improve Safety & Manufacturability of mRNA Delivery
- Evaluate the role of polymers in LNP systems, identify sources of added complexity and toxicity and redesign formulations to maintain performance while simplifying composition
- Optimise lipid-only formulations, improve encapsulation efficiency and delivery performance, reduce variability and enhance manufacturability
- Assess the impact of polymer-free systems on safety, immunogenicity and scalability, enable more robust and clinically viable mRNA delivery platforms