Panagiota Papadopoulou
Marie Skłodowska- Curie Postdoctoral Fellow National Hellenic Research Foundation
I am a lipid nanoparticle specialist. I have 7 years of experience in lipid-based nanoparticle research and formulation and 8+ years of nanomedicine and technology. I am currently working as a postdoctoral researcher in Leiden University with the support of Liposoma BV. My research is focused on liposomal and RNA-LNP therapeutics for Glioblastoma, in collaboration with the Netherlands Cancer Institute (NKI). In 2017, I was awarded the Leiden/Huygens Fellowship from Leiden institute of Chemistry to conduct my PhD research based on the understanding of the in vivo behavior of LNPs and their interactions with biologically relevant proteins. In 2018, I received a certificate in cryo-transmission electron microscopy (cryo-TEM) from TU Eindhoven and ever since I have been investigating the morphological properties of lipid nanoparticles, as part of my PhD research, in the Netherlands Center of Electron Nanoscopy (NeCEN). Besides that and over the years, I have been managing more than 5 research projects, many of which have resulted in impactful research articles and I have been a part of more than 10 other research projects. I have excellent skills in project management, collaboration, LNP technology, microscopy, organic chemistry, peptide chemistry, analytical chemistry and scientific writing. I have industry experience (8 mo at Viohalco group, Greece – ELKEME analytical laboratory) and I have also worked as an external intern in NCSR Demokritos, Greece. I obtained a MSc. in Life Science and Technology (Leiden University, the Netherlands) and a BSc. in Chemistry (NK University of Athens, Greece).
Seminars
- Map intracellular LNP structure and integrity using advanced cryo-EM imaging
- Investigate endosomal escape mechanisms under physiologically relevant conditions
- Link nanoparticle morphology and phase behavior to cell-specific targeting outcomes
- Generate early in vitro and in vivo insights to inform rational LNP design beyond trial-and-error
A practical, end-to-end simulation where participants work through the full lifecycle of an LNP therapy, integrating innovation, CMC and regulatory decision-making to successfully move a candidate toward clinical readiness.
- A practical framework for evaluating LNP designs beyond scientific performance
- Clear understanding of how CMC and regulatory constraints reshape innovation
- Improved ability to make phase-appropriate decisions that accelerate timelines
- Real insight into where most LNP programs fail or stall before clinic
