Panagiota Papadopoulou
Marie Skłodowska- Curie Postdoctoral Fellow National Hellenic Research Foundation
Panagiota Papadopoulou holds a PhD in Bionanotechnology from Leiden University (the Netherlands), where she specialized in lipid nanoparticle design and structure–function relationships in biological environments.
Currently, she is a Marie Skłodowska-Curie Postdoctoral Fellow at the National Hellenic Research Foundation (Athens, Greece), investigating the ultrastructure, intracellular trafficking, and endosomal escape of RNA-LNPs. Her research focuses on linking lipid composition, morphology, and structural integrity to biological fate, using advanced cryo-electron microscopy at the first cryo-EM facility in Greece (cryoUNITe).
Previously, she was a Postdoctoral Researcher at Leiden University, in collaboration with the Netherlands Cancer Institute, where she worked on liposomal and RNA-LNP therapeutics for glioblastoma, contributing to high EU-funded scientific projects (ERC-Synergy). She remains engaged as an external scientific consultant for both organizations.
Seminars
- Map intracellular LNP structure and integrity using advanced cryo-EM imaging
- Investigate endosomal escape mechanisms under physiologically relevant conditions
- Link nanoparticle morphology and phase behavior to cell-specific targeting outcomes
- Generate early in vitro and in vivo insights to inform rational LNP design beyond trial-and-error
A practical, end-to-end simulation where participants work through the full lifecycle of an LNP therapy, integrating innovation, CMC and regulatory decision-making to successfully move a candidate toward clinical readiness.
- A practical framework for evaluating LNP designs beyond scientific performance
- Clear understanding of how CMC and regulatory constraints reshape innovation
- Improved ability to make phase-appropriate decisions that accelerate timelines
- Real insight into where most LNP programs fail or stall before clinic
