Microfluidic Engineering of Milk Extracellular Vesicles for Oral Delivery of siRNA
Time: 10:30 am
day: Day Two
Details:
- Engineering of milk extracellular vesicle (mEV)-lipid nanoparticle (LNP) hybrids using microfluidics for efficient siRNA oral delivery, overcoming RNA loading limitations of natural EVs
- Demonstration of improved safety, distinct uptake pathways, and enhanced delivery efficiency of hybrid particles compared to conventional mEVs and LNPs
- In vivo biodistribution showing promising colon-targeted accumulation after oral administration, highlighting potential for future clinical translation
