Conference Day Two
Tuesday, 26 September
8:00 am Check In & Refreshments
8:45 am Chair’s Opening Remarks
Supercharging Advanced Characterisation Strategies to Translate Structural Data into Functionality Understanding
9:00 am Panel Discussion: Aligning LNP Formulative Innovation with Advanced Analytical Development
Synopsis
- Evolving the perspective of LNP characterisation to keep pace with the development of next-generation LNPs
- Reviewing the current standard of analytical technologies to adequately quantify LNP structure
- Foreseeing the structural components of LNPs which will require more precise quantification to drive characterisation data to the next level
9:15 am Spearheading Novel Approaches to Unravel Mechanisms of LNP Interactions with Endosomal Membranes
Synopsis
- Providing new information about physiological interactions that occur at the site of delivery
- Resolving mechanistic information about LNP interactions at the site to understand the full delivery journey
- Looking towards evolving LNP design to align with the endosomal release required at the site of delivery
9:45 am Outlining Advanced Technology Available to Increase Accuracy of Traditional CQA Touchpoints
Synopsis
- Moving beyond size, shape, zeta potential and encapsulation efficiency to unlock next-generation CQA assessments
- Relaying CQA data to inform adaptations to manufacturing, evolving the process design
- Driving advanced CQA assessment beyond traditional analytical touchpoints to evolve structural understanding
10:15 am Spearheading Novel Approaches to Unravel Mechanisms of LNP Interactions with Endosomal Membranes
Synopsis
- Providing new information about physiological interactions that occur at the site of delivery
- Resolving mechanistic information about LNP interactions at the site to understand the full delivery journey
- Looking towards evolving LNP design to align with the endosomal release required at the site of delivery
10:45 am Lipid-based Nanoparticles: Spatially Resolved DLS as PAT for Inline Nanoparticle Size Characterization and Process Control in Manufacturing
11:00 am Morning Refreshments & Speed Networking
Addressing the Challenges Surrounding Stability Profiling to Ensure Formulation & Manufacturing Processes Protect the LNP Integrity
11:30 am Sharing Cutting-Edge Techniques Implemented to Ensure Stability of LNP Remains Central to Pre-Clinical Studies
Synopsis
Brand New Data!
- Highlighting the structural characteristics of lipids, conjugates and payloads to develop a cohesive and stable LNP
- Uncovering the interplay between charge dynamics and stability
- Enhancing potency over time whilst establishing standardised LNP stability profiles
12:00 pm Lipid-based DNA delivery: towards alternative nucleic acid payloads
Synopsis
Brand New Data!
- Discussing the promises and challenges of DNA payloads as an alternative to mRNA
- Suggesting differences in LNP design when encapsulating different nucleic acid payloads and how the Hermes non-viral delivery platform has been optimized for synthetic DNA payloads
- Leveraging the advantages of synthetic DNA payloads for vaccine and personalized medicine applications
12:30 pm An mRNA-LNP Vaccine Platform Tailoring the Immunogenicity Profile from Prophylactic to Therapeutic Applications, Reducing Reactogenicity and Extending Shelf-Life Stability
Synopsis
- Addressing shortcomings in the immunogenicity, reactogenicity and stability of current mRNA vaccines by optimizing the lipid nanoparticle components
- Investigating the addition of targeting lipids to tune the immunogenicity profile towards the requirements of different prophylactic and therapeutic applications
- Extending the shelf-life of mRNA vaccines by developing lyophilizable LNPs and microneedle-array patches
1:00 pm Scalable Lipid Nanoparticles Formulation using Impingement Jets Mixing Systems
Synopsis
- Scalability of impingement jets mixing (IJM) systems
- Progress in automation of screening
- Data from application partners – scaling up and out
1:15 pm Lunch & Networking
Revealing the Next Generation of LNP Design & Production to Innovate Current Measures of Development
2:15 pm Outlining Next-Generation Perspectives Across Innovative LNP Design
Synopsis
- Reviewing fundamental strategies for extrahepatic targeting, addressing a range of disease indications
- Highlighting the inherent challenges associated with biomolecular corona studies of LNPs
- Questioning whether blebs and empty LNPs can be classified as positive or negative attributes
2:45 pm Meeting Review: The LNP White Space: What Does the Future Hold?
Synopsis
Unite as a community in an ultimate opportunity to celebrate the lessons learned over the past 3 days:
- What are the key takeaways from the presentations and discussions at the summit?
- How do we work more collaboratively as a community to drive progress?
- Where should we be this time next year to classify as a successful year?