Pre Conference Day
Morning Coffee & Workshop Check In
8.00
Workshop A
9.00 - 12.00
LNP 101: Decoding the Structure-Function Relationship in Lipid Nanoparticles
This session is essential for newer entrants to the field to understand how LNP structures influence stability, delivery, and efficacy. By exploring lipid interactions and addressing formulation challenges, participants will gain key insights into the basic groundwork required to design robust LNPs, overcome instability, and set up your new LNP programmes for success.
Key Takeaways:
- Build a foundational understanding of LNP architecture and how structural properties influence delivery performance
- Exploring how lipid components interact to form stable, functional nanoparticles for nucleic acid delivery
- Uncovering the contributing factors of instability in LNPs, and learn strategies to design more robust, scalable formulations
Lunch & Networking
12.00
Workshop B
1.00 - 4.00
Tackling Immunogenicity & Safety Challenges in LNP Development to Minimise Immune Responses & Optimise LNP Efficacy for Successful Clinical Translation
LNP applications continue to grow, ensuring safety and consistency is critical to successful development and clinical use. This workshop will equip you with practical insights into how LNP components impact immune responses and biological interactions, like protein corona formation, helping you anticipate and manage immune activation. You’ll learn how smart lipid design can optimise delivery for diverse targets while minimising adverse effects. Plus, discover the latest advances in PEG alternatives and strategies to mitigate safety risks from LNP heterogeneity, empowering you to develop safer, more reliable LNP therapies with greater confidence and regulatory readiness.
Key Takeaways:
- Unpacking the role of individual LNP components in driving immune responses and influencing protein corona formation
- Exploring lipid design strategies to modulate immune activation in alignment with clinical application requirements
- Evaluating potential alternatives to PEG that retain delivery efficacy while improving accessibility for PEG-sensitive populations
- Addressing safety risks associated with LNP heterogeneity, including the presence of impurities such as empty particles, aggregates, and off-spec particles