Day One: Wednesday, 19th October 2022

7:30 am Morning Registration & Coffee

8:20 am Chair’s Opening Remarks

Evaluating the LNP Landscape

8:30 am Panel Discussion: Setting the Context – Current & Potential Uses of LNPs

Synopsis

Kicking off the summit, hear from industry experts who can set the stage. Given the rapid expansion of the use of LNPs, let’s reset the context and evaluate where we are today.

  • What are the existing uses of LNPs?
  • Where do we see them moving into in the future?
  • What do we have left to face?

9:00 am Pro-Inflammatory Concerns Associated with LNPs

Synopsis

  • Exploring the mechanisms by which nanoparticles trigger an inflammatory response
  • PEG-associated inflammation – how your formulation impacts the response

9:30 am Alternative Systems for Mucosal Delivery of Nucleic Acids

Synopsis

  • Exploring barriers to mucosal (particularly oral) delivery of nucleic acids
  • Outlining an overview of drug delivery systems used for this purpose
  • Delving into extracellular vesicles for oral delivery of nucleic acids

10:00 am Biomolecular Oligonucleotide Assembles for Systemic Delivery of Therapeutic Nucleic Acids

  • Ken Howard Associate Professor, Aarhus University

Synopsis

  • Exploring alternative methods to deliver nucleic acids
  • Discussing advantages: the natural transport properties and ability to tune the PK with recombinant variants of albumin provides the perfect scaffold for biomolecular drug assemblies
  • Incorporation of nucleic acid oligonucleotide modules into the design allows multifunctionalisation and incorporation of therapeutics

10:30am | Speed Networking & Morning Coffee

Delving into On & Off-Target Delivery

11:15 am Biomolecular Oligonucleotide Assembles for Systemic Delivery of Therapeutic Nucleic Acids

  • Ken Howard Associate Professor, Aarhus University

Synopsis

  • Exploring alternative methods to deliver nucleic acids
  • Discussing advantages: the natural transport properties and ability to tune the PK with recombinant variants of albumin provides the perfect scaffold for biomolecular drug assemblies
  • Incorporation of nucleic acid oligonucleotide modules into the design allows
    multifunctionalisation and incorporation of therapeutics

11:45 am Virtual Navigating the IP Landscape for LNP Delivery Technology

Synopsis

  • Surveying the current IP and competitive landscape for LNP delivery technology
  • Considering approaches for licensing and strategic collaborations
  • Reviewing IP protection strategies for new innovations

12:15 pm GenVoy™ Lipid Nanoparticles: A Versatile Tool for Developing RNA Vaccines

Synopsis

  • Delving into successful development of an RNA-LNP: optimal RNA vector design, LNP delivery system and robust manufacturing process
  • Outlining a study where we demonstrate how an early vaccine development workflow can be accelerated from inception to early pre-clinical studies
  • Demonstrating how GenVoy-ILM™ together with the NanoAssemblr® Ignite™ can be used to optimize an RNA-LNP vaccine to illicit potent immune response against the target antigen

12:45pm | Networking Lunch

1:45 pm Panel Discussion: To the Liver & Beyond – Exploring Novel Delivery Areas

Synopsis

  • Modifying the payload to reach extrahepatic locations
  • Exploring novel formulation methods for improved delivery of LNPs
  • What challenges are faced?

2:15 pm Session reserved for Wyatt Technology

Maximising LNP Formulation Methods for Improved Processes

2:45 pm Spray Drying of LNPs Enables Intratracheal Delivery of mRNA

  • Kristina Friis Senior Scientist, Advanced Drug Delivery , AstraZeneca

Synopsis

  • Diving into the key parameters required to facilitate spray drying of LNPs
  • Enhancing LNP stability, cellular uptake and RNA delivery to the lung
  • Exploring potential for future applications including inhaled vaccines

3:15 pm Compliant Scalability of LNP Manufacture from Lab to 1 Billion Dose

Synopsis

  • A process engineering approach to scale up (not scale out)
  • End-to-end process considerations
  • PAT and the appropriate process analytics

3:30pm | Afternoon Break & Poster Session

4:00 pm Utilising Small-Angle Neutron Scattering (SANS) to Understand the Structure of LNPs

  • Zongyi Li Post-Doctoral Researcher , University of Manchester

Synopsis

  • What LNPs structure information can SANS tell?
  • Understanding LNP structure evolution during pH changes
  • Exploring a potential approach to link LNP formulation, structure, and function

4:30 pm Automated High-Throughput Screening of LNP Formulations

  • Ben Knappett Head of Science & Applications, Particle Works

Synopsis

  • Outlining the current challenges
  • Delving into the benefits of microfluidic technology
  • Employing automated mRNA-LNP formulation screening

4:45 pm Delivering RNA to Neutrons In Vitro & In Vivo

5:15 pm Chair’s Closing Remarks & End of Day One

WORKSHOP DAY
DAY TWO