Conference Day One

8:00 am Check In & Breakfast

9:00 am Chair’s Opening Remarks

Advancing LNP Stability to Enable Thermostable Formulations for Global Equitable Access

9:15 am Stability by Design – Getting to Long Term Stable RNA Based Products

Synopsis

  • Rational design and selection of a robust LNP platform to support long-term storage and stability, enabling broader therapeutic application and streamlined supply chain logistics
  • Strategic liver de-targeting through intelligent LNP design, reducing off-target effects and enhancing tissue-specific delivery
  • Utilizating a platform in product development and CMC workflows, ensuring seamless scalability, regulatory alignment, and clinical readiness

9:45 am Separating LNP Manufacture from Cargo Incorporation: The Route to Globally Accessible and Personalised RNA Therapeutics

Synopsis

  • Understanding the need to introduce RNA payload during LNP formation and the resulting ultra-cold chain requirements limiting the suitability of LNPs for global vaccine rollouts or for small batch production of personalized medicine
  • SiSaf has developed silicon stabilized hybrid LNPs (sshLNPs) that can be produced empty and loaded with RNA cargo in a separate step
  • sshLNPs can not only be stored and shipped at fridge temperature but they also offer other key advantages over conventional LNPs, such as enhanced safety, RNA stability, transfection efficiency and non-hepatic delivery

10:15 am Session Details to be Revealed

10:45 am Morning Break & Speed Networking

Synopsis

Join our speed networking session tailored for LNP professionals, like yourselves, to connect with fellow industry peers to facilitate rapid yet meaningful exchanges of insights and expertise. Elevate your networking experience during this session designed for impactful connections within the space.

Delivery Without Limits: Tailoring LNPs to Navigate Biological Barriers Through Optimised Delivery Routes

11:45 am Immunological Compatibility of Advanced Nanotherapeutics: Mechanistic Insights & Clinical Translation

  • Neill Liptrott Professor of Pharmacology & Immunocompatibility, University of Liverpool

Synopsis

  • Understanding how nanoparticle properties like size, charge, and composition drive immune activation pathways to enable the design of safer, more targeted nanomedicines
  • Leveraging advanced metabolic and immunotoxicity assays, backed by harmonised protocols (ASTM, EUNCL, IDDC), to ensure reliable data and facilitate regulatory approval
  • Gaining translational insights from LNP vaccine case studies and global regulatory contributions, helping accelerate product development and build confidence in emerging
  • formulations

12:15 pm Designing Lipid Nanoparticles for Transport Across the Blood-Brain Barrier for CNS Diseases

  • Kamalinder Kaur Singh Professor - Pharmaceutical Technology & Drug Delivery, University of Central Lancashire

Synopsis

  • Optimising LNP design to increase transportation across the BBB
  • Overcoming challenges to improve target cell penetration
  • Exploring LNPs for targeted glioblastoma therapy

12:45 pm Lunch Break & Networking

Outrunning the Liver: Targeting Non-Hepatic Tissues for More Precise Drug Delivery, Reduced Off-Target Effects, & Enhanced Therapeutic Efficacy

1:45 pm Lipid Nano Particle Extrahepatic Delivery: Active & Passive Target

  • Kinkini Roy Associate Director, Drug Product Development, Aviceda Therapeutics

Synopsis

  • Is passive targeting efficient enough for extrahepatic targeting?
  • Exploring ligand mediated selection for extrahepatic delivery
  • Delving into new routes of administration

2:15 pm Session Details to be Revealed

2:25 pm Roundtable Discussion: Engineering LNPs for the Real World: Strategies to Enhance Stability, Transfection Efficiency & Cold Chain Flexibility

Synopsis

  • What stable lipids and excipients are the most effective in enhancing LNP resilience to thermal stress and maintaining longterm stability?
  • Understanding how lipid design influences bleb formation, and what is its downstream effects on transfection potency
  • Exploring strategies to retain LNP efficiency at lower storage temperatures without compromising integrity or activity

3:00 pm Afternoon Break & Poster Presentation Session

4:00 pm Enhancing RNA Cell Specificity with Enhanced Intracellular Delivery

  • Alexander Kros Professor of supramolecular & Biomaterials Chemistry, Leiden University

Synopsis

  • Developing targeted LNPs for cell-specific delivery to extra hepatic tissues, expanding therapeutic reach beyond the liver
  • Enhancing endosomal escape to improve intracellular RNA release and increase overall delivery efficiency
  • Engineering internal nanoparticle structure to optimize RNA payload stability, release kinetics, and safety profile

4:30 pm Unlocking Targeted Delivery with Peptide Systems by Overcoming Stability Challenges & Avoiding Degradation to Induce Therapeutic Interventions in Desired Tissues

Synopsis

  • Addressing peptide stability issues through chemical modifications and new formulation approaches, enhancing their shelf-life and efficacy in vivo
  • Improving targeting precision by optimizing peptide sequences and conjugation strategies, ensuring specific delivery to disease sites with minimal off-target effects
  • Exploring hybrid peptide platforms to combine the advantages of peptides with other nanoparticle systems, enabling more effective delivery for therapeutic success

5:00 pm Chair’s Closing Remarks

5:15 pm End of Conference Day One